Figure 1B

Cell type-specific probability maps for four examples of melanoma slides from distinct microenvironments: immune-depleted (D), fibrotic (F), immune-enriched fibrotic (IE/F) and immune-enriched (IE) subtypes.

** Note that the full slide is shown here. **

Figure 2

Slide-level quantification of each cell type Co-localization assessment of cell type pairs across the distinct microenvironment subtypes

Figure 4

Number of shortest paths with maximum path length equal to two (SP2). Size of the largest connected component (LCC) Proximity between cell type-specific clusters classified as highly or lowly abundant.

Figure 5

Two slides classified as IE subtypes Two slides classified as F subtypes which were predicted to have similar cell type abundance

Figure 6

Hazard ratio (HR) estimate calculated based on univariate cox regression analysis of TCGA overall survival (n=320; deceased = 153) showing the estimated HR (dots) and the 95% confidence interval (bars). Positive (red) and negative (green) HR means that the feature is associated with decreased and increased survival respectively.

Corresponding receiver operating characteristic (ROC) curve for prediction of 1-year vital status in the CPTAC melanoma cohort (n=36 patients: deceased = 4, living = 32).

Bar plots showing the elastic-net logistic regression model coefficients for 13 recurrent features (non-zero in >50% of the bootstrap runs).

Kaplan-Meier (KM) curves displaying the estimated survival probability for two different groups (low and high) defined according to the values of corresponding spatial features.